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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SAMHD1
All Species:
16.97
Human Site:
S278
Identified Species:
31.11
UniProt:
Q9Y3Z3
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y3Z3
NP_056289.2
626
72201
S278
Q
I
V
G
P
L
E
S
P
V
E
D
S
L
W
Chimpanzee
Pan troglodytes
XP_514624
382
43769
V63
R
G
G
F
E
E
L
V
L
L
K
N
I
R
E
Rhesus Macaque
Macaca mulatta
XP_001097562
728
83194
S380
Q
I
V
G
P
L
E
S
P
V
K
G
V
L
W
Dog
Lupus familis
XP_542986
665
76981
T316
Q
I
T
G
P
L
E
T
P
I
K
D
S
L
W
Cat
Felis silvestris
Mouse
Mus musculus
Q60710
627
72632
T279
Q
I
M
G
P
P
I
T
P
V
K
D
S
L
W
Rat
Rattus norvegicus
XP_230789
677
77635
S334
Q
I
M
G
P
P
V
S
P
V
K
D
C
L
W
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZJL9
614
70202
E269
Q
I
G
G
P
I
D
E
T
A
C
E
E
S
W
Frog
Xenopus laevis
Q6INN8
632
72730
S283
E
A
E
Q
Q
F
N
S
S
P
N
S
S
S
W
Zebra Danio
Brachydanio rerio
Q502K2
622
71649
A258
I
A
G
P
L
E
S
A
V
L
D
Q
S
Q
W
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q09374
587
66474
F244
G
P
E
K
S
F
L
F
D
V
V
S
N
S
Y
Sea Urchin
Strong. purpuratus
XP_784786
594
68895
P252
I
R
E
Q
I
E
G
P
M
Y
N
D
N
E
W
Poplar Tree
Populus trichocarpa
XP_002312899
477
54770
D158
Q
M
S
T
K
M
V
D
H
I
V
D
K
H
H
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_568580
473
54655
I154
E
L
M
S
V
N
M
I
D
H
M
V
D
T
H
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
58.9
79.5
73.5
N.A.
73.3
65.8
N.A.
N.A.
60
61.8
60.8
N.A.
N.A.
N.A.
22.5
46.8
Protein Similarity:
100
60.2
82.4
83.6
N.A.
83.2
76.2
N.A.
N.A.
74.9
75.3
74.1
N.A.
N.A.
N.A.
40.8
64.2
P-Site Identity:
100
0
80
73.3
N.A.
66.6
66.6
N.A.
N.A.
33.3
20
13.3
N.A.
N.A.
N.A.
6.6
13.3
P-Site Similarity:
100
26.6
86.6
93.3
N.A.
86.6
80
N.A.
N.A.
53.3
26.6
33.3
N.A.
N.A.
N.A.
20
20
Percent
Protein Identity:
28.2
N.A.
N.A.
30.5
N.A.
N.A.
Protein Similarity:
45
N.A.
N.A.
47.2
N.A.
N.A.
P-Site Identity:
13.3
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
33.3
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
16
0
0
0
0
0
8
0
8
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
8
0
8
0
0
% C
% Asp:
0
0
0
0
0
0
8
8
16
0
8
47
8
0
0
% D
% Glu:
16
0
24
0
8
24
24
8
0
0
8
8
8
8
8
% E
% Phe:
0
0
0
8
0
16
0
8
0
0
0
0
0
0
0
% F
% Gly:
8
8
24
47
0
0
8
0
0
0
0
8
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
8
8
0
0
0
8
16
% H
% Ile:
16
47
0
0
8
8
8
8
0
16
0
0
8
0
0
% I
% Lys:
0
0
0
8
8
0
0
0
0
0
39
0
8
0
0
% K
% Leu:
0
8
0
0
8
24
16
0
8
16
0
0
0
39
0
% L
% Met:
0
8
24
0
0
8
8
0
8
0
8
0
0
0
0
% M
% Asn:
0
0
0
0
0
8
8
0
0
0
16
8
16
0
0
% N
% Pro:
0
8
0
8
47
16
0
8
39
8
0
0
0
0
0
% P
% Gln:
54
0
0
16
8
0
0
0
0
0
0
8
0
8
0
% Q
% Arg:
8
8
0
0
0
0
0
0
0
0
0
0
0
8
0
% R
% Ser:
0
0
8
8
8
0
8
31
8
0
0
16
39
24
0
% S
% Thr:
0
0
8
8
0
0
0
16
8
0
0
0
0
8
0
% T
% Val:
0
0
16
0
8
0
16
8
8
39
16
8
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
70
% W
% Tyr:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _